Early recognition and treatment of sepsis are crucial for improving patient outcomes, leading to clinical guidelines recommending sepsis screening programmes. However, evidence supporting these progr
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Sepsis is a major cause of mortality worldwide, with intravenous crystalloid infusion being the first-line treatment to maintain organ perfusion. However, fluid overload is associated with poor...
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Sepsis is a major but often overlooked cause of death and disability. In 2017, there were an estimated 48.9 million cases of sepsis, causing 11 million deaths worldwide. Sepsis is more comm
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Sepsis, as defined by Sepsis-3, is a life-threatening organ dysfunction caused by a dysregulated response to infection, with high mortality rates, especially in septic shock. Sepsis can cause acute...
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Vasopressors are commonly used in critically ill patients to increase vascular tone in cases of severe hypotension with signs of altered tissue perfusion, such as poor skin perfusion, altered mental...
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Dementia is a progressive neurodegenerative disease with growing public health and economic implications. In 2019, 57.4 million people had dementia worldwide, a number projected to reach 152.8 millio
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Sepsis remains a leading cause of morbidity and mortality, requiring rapid and precise intervention to improve patient outcomes. Early detection and management are critical, as delayed trea
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Over 50 RCTs have examined resuscitation strategies in sepsis, but the optimal approach remains unclear. Early goal-directed therapy (EGDT), a 6-hour protocol involving fluids, vasopressors, inotrope
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Sepsis is a life-threatening condition caused by a dysregulated host response to infection, leading to organ dysfunction. Sepsis involves both pro-inflammatory and anti-inflammatory processes, which...
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Sepsis is a common cause of ICU admissions and mortality, with its incidence increasing over recent decades. Although hospital mortality has declined, long-term mortality remains high, with
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